Your feelings of self-worth and self-competency can also be affected when you’re going through an emotional life event, losing a loved one, changes in your job, relocating to a different city, or illness. changes can influence your understanding of yourself, in relation to the world around you, your various roles and identities. You may have lost the responsibilities of being a partner, parent, provider, decision-maker, or expert. Sometimes, losing the sense of who you are and why you’re here comes a loss of self-esteem. We’re all affected to some degree by life changes, but if you’re extremely vulnerable this upsets, can result in depression.